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Zofran is a brand name for the drug ondansetron, prescribed to treat or prevent nausea and vomiting.
Doctors sometimes prescribe Zofran to treat nausea and vomiting caused by cancer treatments such as chemotherapy and radiation therapy.
Zofran also can treat nausea and vomiting after surgery.
The drug may also help prevent the common complication of shivering in people who have had anesthesia.
Some doctors have prescribed Zofran off-label to treat nausea and vomiting caused by morning sickness in pregnant women, though the drug has never been approved for this use.
Zofran blocks serotonin, a natural substance in the brain that may contribute to nausea and vomiting.
It belongs to a class of drugs called serotonin 5-HT3 receptor antagonists.
These drugs are antiemetics, meaning they block nausea and vomiting.
The Food and Drug Administration (FDA) approved ondansetron in 1992 under the brand name Zofran for GlaxoSmithKline.
In 2007, the FDA approved generic ondansetron for several drug companies.
Zofran Warnings One form of ondansetron is a rapidly dissolving tablet (Zofran ODT).
If you use Zofran ODT, do not remove the tablet from its foil pocket until just before you take it.
You should not take Zofran if you take a drug called apomorphine, which is an injectable drug used to treat Parkinson’s disease.
The combination of apomorphine and ondansetron can cause dangerously low blood pressure.
You also should not use Zofran if you’ve had an allergic reaction to a different serotonin 5-HT3 receptor antagonist.
Brand names of these include Lotronex, Anzemet, Kytril, and Aloxi.
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