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Additional information about the drug Dramamine

Dramamine, marketed as Dramamine and Gravol among others, is an over-the-counter medication used to treat motion sickness and nausea. Dramamine is a combination, or a salt of two drugs: diphenhydramine and 8-chlorotheophylline.
It is most commonly prepared as tablets, although it is also available in liquid form and as a suppository.
1 Medical uses
2 Recreational use
3 Veterinary use
4 Brand names
5 References
6 External links
Medical uses
Dramamine is primarily used to treat nausea, vomiting, and dizziness caused by motion sickness. Dramamine has also been found to aid in the treatment of ear congestion.
Diphenhydramine is the primary constituent of dimenhydrinate and dictates the primary effect. The main difference relative to pure diphenhydramine is a lower potency due to being combined with 8-chlorotheophylline. By weight, dimenhydrinate is between 53% to 55.5% diphenhydramine.
8-Chlorotheophylline, a chlorinated derivative of theophylline, was added in order to counteract drowsiness. Theophylline is very closely related to caffeine and theobromine, mild central nervous system stimulants. It was thought by scientists
Recreational use
Dramamine is recreationally used as a deliriant.
Many users report a side effect profile consistent with tropane alkaloid (e.g. atropine ) poisoning as both show antagonism of muscarinic acetylcholine receptors in both the central and autonomic nervous system, which inhibits various signal transduction pathways. In the CNS, diphenhydramine readily crosses the blood-brain barrier, exerting effects within the visual and auditory cortex.
Antiemetics described here include: the dopamine antagonists such as metoclopramide and chlorpromazine hydrochloride; antihistamines such as dimenhydrinate, meclizine hydrochloride and promethazine hydrochloride; and the phenothiazine thiethylperazine maleate.

  • One woman became dependent on dimenhydrinate (which is 55% diphenhydramine) during her first pregnancy and continued to take it in a dose of 150 mg (83 mg diphenhydramine) daily while she breastfed her infant for 3 months.
  • Drugs in this classinclude diphenhydramine (Benadryl), dimenhydrinate (Dramamine), chlorpheni-ramine (Chlor-Trimeton, Teldrin), promethazine (Phenergan), and meclizine (Antivert).a. Ongoing histamine effects are only weakly reduced; thus, the H1-antihistamineswork best if administered before exposure to an allergen.b. The activity against acute allergic reactions is better than the activity in chronicallergies.c. There are many clinical uses for H1 antihistamines, including treatment ofi.
  • Dramamine: (Moderate) Sedating H1-blockers are associated with sedation; therefore, additive effects may be seen during concurrent use with other drugs having CNS depressant properties such as antipsychotics.
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