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Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B.
It is a prodrug, which is converted to aciclovir in a persons body.
Valaciclovir was approved for medical use in 1995.
1 Medical use
2 Adverse effects
3 Mechanism of action
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Valaciclovir is indicated for the treatment of HSV and VZV infections, including:
Oral and genital herpes simplex (treatment and prophylaxis )
Reduction of HSV transmission from people with recurrent infection to uninfected individuals
Herpes zoster (shingles): the typical dosage for treatment of herpes is 1,000 mg orally three times a day for seven consecutive days.
Prevention of cytomegalovirus following organ transplantation
Prophylaxis against herpesviruses in immunocompromised patients (such as patients undergoing cancer chemotherapy)
It has shown promise as a treatment for infectious mononucleosis,
Common adverse drug reactions (≥1% of patients) associated with valaciclovir therapy are the same as for aciclovir, its active metabolite, and include: nausea, vomiting, diarrhea and headache. Infrequent adverse effects (0.1–1% of patients) include: agitation, vertigo, confusion, dizziness, edema, arthralgia, sore throat, constipation, abdominal pain, rash, weakness and/or renal impairment. Rare adverse effects (
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