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Tofranil, sold under the brand names Tofranil and Tofranil PM, is the generic name of a prescription drug used to treat depression.
It may also be prescribed off-label as a non-narcotic medicine to relieve chronic pain.
Tofranil belongs to a group of drugs known as tricyclic antidepressants, or TCAs.
While TCAs have been on the market for decades, scientists are still unclear as to exactly how these drugs work.
However, they do know that they interfere with the body’s ability to draw norepinephrine and serotonin back up into nerve endings called synapses.
This increases the concentrations of these chemicals in the brain.
Originally manufactured by Sanofi Aventis, the Food and Drug Administration (FDA) first approved imipramine under the brand name Presamine in 1959.
Presamine was later discontinued.
Tofranil Warnings Like all antidepressants, imipramine carries a black-box warning because some people may become severely depressed and suicidal while taking the drug.
Talk to your doctors about the risks of suicide ideation before taking imipramine or any other antidepressant.
You shouldn’t take imipramine if: You’re allergic to imipramine or any of the drug’s inactive ingredients You just had a heart attack Ask your doctor about imipramine if you: Have glaucoma or other issues with increased pressure in the eye Have seizures Suffer from hormonal disorders like diabetes or thyroid disease Have Parkinson’s disease Have mood disorders, like schizophrenia or bipolar disorder Live in an extremely warm climate Have heart conditions, including congestive heart failure (CHF) or a slow or irregular heartbeat Just had a heart attack You’re younger than 25 or older than 65 Also, don’t expect to notice a big difference in your mood when you first start taking imipramine.
Regardless of the dose prescribed, imipramine — like most antidepressants — can take up to three or four weeks before you either notice a change or see the maximum effect of the dose you’re taking.
BasicDescription Back to Top Tofranil Side Effects Common Side Effects of Tofranil You should tell your doctor if any of the following side effects are severe or don’t go away: Difficulty sleeping Weakness Confusion Dry mouth Increased appetite Nausea, vomiting Constipation Racing or fast heartbeat Rash or itching Blurry vision Sweatiness Serious Side Effects of Tofranil You should stop using this medicine and call your doctor if you experience any of the following serious side effects: Dizziness upon standing, fainting Stroke, heart attack, or changes in heart rhythm Seizures Parkinson’s-like signs, such as hand tremors, pill-rolling of the hands, or dragging of the feet Blood abnormalities, like low white blood cell count and low levels of platelets, white blood cells, and red blood cells Suicidal thoughts Syndrome of inappropriate antidiuretic hormone (SIADH) Back to Top Tofranil Interactions You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you’re taking.
Don’t take imipramine if you are taking the following drugs: KlorCon (potassium phosphate) Drugs for bowel preparation, like potassium phosphate or potassium citrate Flumazenil Drugs for irregular heartbeat like dronedarone, Norpace or Norpace CR (disopyramide), and procainamide Parnate (tranylcypromine) Zyvox (linezolid) Emsam (selegiline transdermal) Like most TCAs, imipramine interacts with many drugs, so please discuss any concerns with your doctor or pharmacist before taking it.
Other drugs that interact with imipramine include: Cordarone, Nexterone, or Pacerone (amiodarone) Drugs for irregular heartbeat, like Tikosyn (dofetilide), dobutamine, and Betapace or Betapace AF ( sotalol ) Tagamet (cimetidine) Ephedra and ephedrine Epi-Pen, Epi-Pen, Jr.
( epinephrine ) Methadose and Dolophine (methadone) Biaxin (clarithromycin) Tofranil and Alcohol Impramine and alcohol can both cause dry mouth, dry eyes, dizziness, and confusion.
Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia.Cognitive-behavioral therapy helps prevent relapse and recurrence of panic disorder following alprazolam discontinuation: a long-term follow-up of the Peoria and Dartmouth studies.He is the Ruth E. Murdaugh Professor of Family Medicine, head of behavioral science, and director of the family stress clinic at the University of Virginia School of Medicine.
Back to Top Tofranil Dosage Generic imipramine is available in tablet form in the same doses as those found in Tofranil and Tofranil PM. Decreases number of awakenings from sleep, markedly reduces time in REM sleep, and increases stage 4Relief of nocturnal enuresis is perhaps due to anticholinergic activity and to nervous system stimulation,Tofranil is the only TCA used as temporary adjuvant treatmentCNS: Sedation, drowsiness, dizziness, headache, fatigue, numbness, tingling (paresthesias) of extremities; incoordination, ataxia, tremors, peripheralCV: Orthostatic hypotension, mild sinus tachycardia; arrhythmias, hypertension or hypotension, palpitation, MI, CHF, heart block, ECG changes, stroke, flushing, cold cyanotic hands and feet (peripheral vasospasm). Management: Pharmacotherapy: The tricyclic antidepressant, imipramine, the MAO inhibitor, Phenelzine and the high potency bendodiazepine Alprazolam have been shown to be effective blockers of spontaneous panic attacks.
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