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Singulair is the brand name of montelukast, a drug prescribed for people with asthma.
Singulair helps prevent the wheezing and shortness of breath caused by asthma attacks.
Singulair can also help decrease the frequency of asthma attacks, and it may be used to relieve the symptoms of hay fever, allergic rhinitis, and other allergies that cause sneezing and stuffy, runny, or itchy nose.
You can also take it to prevent exercise-induced asthma.
Singulair works by blocking certain natural substances called leukotrienes that may cause or worsen asthma and allergies.
Leukotrienes — chemicals your body releases when you breathe in an allergen, such as pollen — cause swelling in your lungs and tightening of the muscles around your airways, which can result in asthma symptoms.
Singulair is made by Merck and was approved for use by the Food and Drug Administration (FDA) in 1998 for treatment of asthma-related symptoms.
The FDA has approved several generic versions of montelukast, but Singulair continues to be the most popular prescribed brand.
In 2008, the FDA announced that it would investigate whether mood changes and suicidal thoughts were possible side effects of leukotriene modulator drugs, including Singulair.
Clinical trials revealed only an increased risk of insomnia, but surveys showed that the drugs are also associated with a possible increase in suicidal behavior, agitation, aggression, irritability, hallucinations, and depression.
Singulair Warnings Singulair will not work fast enough to treat an asthma attack that has already begun.
You should use a fast-acting inhalation medicine to treat an asthma attack.
It may take up to several weeks before your symptoms improve after starting Singulair.
You should call your doctor right away if you feel Singulair is not working as well as usual, or if it makes your condition worse.
If it seems like you need to use more of any of your medications, including Singulair in a 24-hour period, talk with your doctor.
Before using Singulair, tell your doctor about your complete medical history, especially if you have liver disease (in some reports, the drug has been associated with liver damage).
Leukotriene antagonists (zileuton, montelukast, and zafirlukast) inhibit the synthesis ofleukotrienes (which are products of arachidonic acid metabolism) or their receptor binding (see Fig. 50. 7). Leukotriene modifiers have both mild bronchodilator and anti-inflammatory properties.
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