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Additional information about the drug Prilosec

Prilosec is the brand name of the drug omeprazole, which is used to treat symptoms of gastroesophageal reflux disease (GERD).
GERD happens when acid from the stomach flows backward into the esophagus (the tube between the throat and the stomach).
It can cause heartburn and injure the esophagus.
Prilosec is also used to treat erosive esophagitis and Zollinger-Ellison syndrome (a condition in which the stomach produces too much acid).
And Prilosec may be used to prevent upper gastrointestinal bleeding in critically ill patients, and is part of the treatment for an infection of Helicobacter pylori, a type of bacteria that can cause stomach ulcers.
Prilosec is in a class of drugs called proton pump inhibitors (PPIs).
These medicines block production of stomach acid.
The medicine is available in a prescription and over-the-counter (OTC) form.
It was approved by the Food and Drug Administration (FDA) in 1989.
Prilosec Warnings You should take Prilosec exactly as prescribed or as directed on the OTC package label.
Do not take the nonprescription form of Prilosec for longer than 14 days or use the drug more often than once every four months without first talking to your doctor.
Prilosec is not intended for immediate symptom relief.
It may take up to four days for you to feel the full benefit of this medication.
You should call your doctor if your symptoms worsen or do not improve after 14 days of taking the drug.
Also, contact your physician if your symptoms return sooner than four months after you finish treatment with Prilosec.
You should continue to take Prilosec even if you feel well.
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  • In comparison with histamine H 2 -receptor antagonists, the median increases produced by 20 mg doses of omeprazole were higher (1.3 to 3.6 fold vs. 1.1 to 1.8 fold increase). Gastrin values returned to pretreatment levels, usually within 1 to 2 weeks after discontinuation of therapy.
  • In order to assess the relief from heartburn and from other symptoms of GERD after 3 days of treatment with standard-dose rabeprazole or high-dose omeprazole, healing rates and quantification of antacid use, Holtmann et al (2002) studied 230 patients with endoscopically confirmed erosive esophagitis that were randomized to receive 4 weeks of double-blind treatment with rabeprazole (20 mg) or omeprazole (40 mg).
  • Dose reduction is required in moderate-severe renal insufficiency and in possibly severe hepatic insufficiency. A PPI is absorbed from intestinal mucosa and diffuses readily into parietal cell canaliculi, where it becomes protonated and is concentrated by Henderson-Hasselbalch trapping.Esomeprazole and pantoprazole are also available in formulations for intravenous administration.
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