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Progesterone
Progesterone is a prescription medication used to promote normal menstrual periods in women who are premenopausal but have stopped having periods due to low progesterone levels. Progesterone is also used in combination with estrogen-containing medications in postmenopausal women with a uterus to reduce the risk of developing cancer of the uterus and to prevent abnormal thickening of the lining of the uterus in women taking estrogen. Progesterone is also used to promote embryo implantation and pregnancy in conjunction with fertility treatments in women. 
Progesterone belongs to a group of drugs called progestins. These work to acheive various effects in the body by mimicking the effects of naturally occuring hormones.
This medication comes in a capsule form and is typically taken once a day, at bedtime, for 10 or 12 continuous days, depending on the condition being treated.
This medication is also available in a vaginal insert form that is typically inserted into the vagina 2 to 3 times daily for up to 10 weeks of treatment.
This medication is also available in a gel form that is typically applied to the vagina once or twice a day. The frequency of application depends on the condition being treated. 
This medication is also available in an injectable form to be given directly into a muscle by a healthcare provider, typically daily, for 6 to 8 days.
Common side effects of progesterone include headaches, breast pain, and irregular vaginal bleeding or spotting.
Progesterone can also cause dizziness and/or drowsiness. Do not drive or operate heavy machinery until you know how progesterone affects you.
Progesterone is a prescription medication used to promote normal menstrual periods in women who are premenopausal but have stopped having periods due to low progesterone levels. Progesterone is also used in combination with estrogen-containing medications in postmenopausal women with a uterus to reduce the risk of developing cancer of the uterus and to prevent abnormal thickening of the lining of the uterus in women taking estrogen. Progesterone is also used to promote embryo implantation and pregnancy in conjunction with fertility treatments in women. 
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Progesterone may be found in some form under the following brand names:
Progesterone is part of the drug class:
Serious side effects have been reported with progesterone. See the “Progesterone Precautions” section.
Common side effects of progesterone include the following:
This is not a complete list of progesterone side effects. Ask your doctor or pharmacist for more information.
Tell your doctor if you have any side effect that bothers you or that does not go away.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
 This is not a complete list of progesterone] drug interactions. Ask your doctor or pharmacist for more information.
Serious side effects have been reported with progesterone including the following:
Do not take progesterone capsules if you are allergic to peanuts. 
Progesterone can also cause dizziness and/or drowsiness. Do not drive or operate heavy machinery until you know how progesterone affects you.
Grapefruit and grapefruit juice may interact with progesterone and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
Before taking progesterone, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories – A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Progesterone  falls into category B.  There are no well-designed studies that have been done in humans with progesterone. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.
Tell your doctor if you are breastfeeding or plan to breastfeed.
Progesterone has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from progesterone, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.
Take progesterone exactly as prescribed.
Progesterone comes in a capsule form and is typically taken once a day, at bedtime, for 10 or 12 continuous days depending on the condition being treated.
Progesterone is also available in a vaginal insert form that is typically inserted into the vagina 2 to 3 times daily for up to 10 weeks of treatment.
Progesterone is also available in a gel form that is typically applied to the vagina once or twice a day. The frequency of application depends on the condition being treated. 
Progesterone is also available in an injectable form to be given directly into a muscle by a healthcare provider, typically daily, for 6 to 8 days.
To administer progesterone vaginal inserts:
If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of progesterone at the same time.
Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
The dose your doctor recommends may be based on the following:
The recommended dose of progesterone to promote embryo implantation and pregnancy in conjunction with fertility treatments in women is 100 mg administered two or three times daily for up to 10 weeks total duration
If you take too much progesterone, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

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