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Paxil is the brand name for the antidepressant paroxetine.
Though doctors prescribe Paxil to treat depression, it’s also used to treat anxiety disorders including: Panic disorder Social anxiety disorder Generalized anxiety disorder (GAD) Post-traumatic stress disorder (PTSD) Obsessive-compulsive disorder (OCD) Paxil is also approved by Food and Drug Administration (FDA) to help women manage the hot flashes associated with menopause.
Additionally, doctors may prescribe Paxil off-label to treat conditions other than those for which it has been approved by the FDA.
For example, some doctors prescribe Paxil to treat chronic headaches, and people with diabetes may use the drug to help alleviate tingling in the hands and feet.
Paxil has also been used to treat men who experience premature ejaculation.
A controlled-release form, Paxil CR, can relieve the physical and psychological symptoms some women experience before their menstrual cycle begins each month.
Paxil belongs to a class of antidepressant medications called selective serotonin-reuptake inhibitors (SSRIs).
SSRIs work by boosting levels of serotonin, a neurotransmitter that helps the brain send messages from one nerve cell to another.
Paxil History GlaxoSmithKline makes Paxil, which the FDA first approved in 2001.
Paxil is also available under the brand names Brisdelle and Pexeva.
Generic forms of paroxetine became available in 2003.
GlaxoSmithKline has repeatedly come under fire for its marketing of Paxil and other antidepressants, including accusations that the company misreported data from clinical trials, which showed that Paxil might be unsafe for teenagers and young adults.
In 2012, GlaxoSmithKline agreed to pay a $3 billion fine to U.S.
federal prosecutors, in part for its antidepressant marketing practices.
A study published in the medical journal BMJ in 2015 reanalyzed data from 2001 and found that Paxil was ineffective at treating depression in adolescents.
Additionally, the study found that use of the drug among adolescents was associated with significant harm, including thoughts of suicide and suicide attempts.
Patients should be periodically reassessed to determine the need for continued treatment. When treating pregnant women with paroxetine during the third trimester, the physician should carefully consider the potential risks and benefits of treatment. Conversely, at least 14 days should be allowed after stopping paroxetine extended-release tablets before starting an MAOI intended to treat psychiatric disorders (see CONTRAINDICATIONS ). In a patient who requires more urgent treatment of a psychiatric condition, other interventions, including hospitalization, should be considered (see CONTRAINDICATIONS ). If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patient, paroxetine extended-release tablets should be stopped promptly, and linezolid or intravenous methylene blue can be administered.
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