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Additional information about the drug Tofranil

Tofranil, sold under the brand names Tofranil and Tofranil PM, is the generic name of a prescription drug used to treat depression.
It may also be prescribed off-label as a non-narcotic medicine to relieve chronic pain.
Tofranil belongs to a group of drugs known as tricyclic antidepressants, or TCAs.
While TCAs have been on the market for decades, scientists are still unclear as to exactly how these drugs work.
However, they do know that they interfere with the body’s ability to draw norepinephrine and serotonin back up into nerve endings called synapses.
This increases the concentrations of these chemicals in the brain.
Originally manufactured by Sanofi Aventis, the Food and Drug Administration (FDA) first approved imipramine under the brand name Presamine in 1959.
Presamine was later discontinued.
Tofranil Warnings Like all antidepressants, imipramine carries a black-box warning because some people may become severely depressed and suicidal while taking the drug.
Talk to your doctors about the risks of suicide ideation before taking imipramine or any other antidepressant.
You shouldn’t take imipramine if: You’re allergic to imipramine or any of the drug’s inactive ingredients You just had a heart attack Ask your doctor about imipramine if you: Have glaucoma or other issues with increased pressure in the eye Have seizures Suffer from hormonal disorders like diabetes or thyroid disease Have Parkinson’s disease Have mood disorders, like schizophrenia or bipolar disorder Live in an extremely warm climate Have heart conditions, including congestive heart failure (CHF) or a slow or irregular heartbeat Just had a heart attack You’re younger than 25 or older than 65 Also, don’t expect to notice a big difference in your mood when you first start taking imipramine.
Regardless of the dose prescribed, imipramine — like most antidepressants — can take up to three or four weeks before you either notice a change or see the maximum effect of the dose you’re taking.
BasicDescription Back to Top Tofranil Side Effects Common Side Effects of Tofranil You should tell your doctor if any of the following side effects are severe or don’t go away: Difficulty sleeping Weakness Confusion Dry mouth Increased appetite Nausea, vomiting Constipation Racing or fast heartbeat Rash or itching Blurry vision Sweatiness Serious Side Effects of Tofranil You should stop using this medicine and call your doctor if you experience any of the following serious side effects: Dizziness upon standing, fainting Stroke, heart attack, or changes in heart rhythm Seizures Parkinson’s-like signs, such as hand tremors, pill-rolling of the hands, or dragging of the feet Blood abnormalities, like low white blood cell count and low levels of platelets, white blood cells, and red blood cells Suicidal thoughts Syndrome of inappropriate antidiuretic hormone (SIADH) Back to Top Tofranil Interactions You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you’re taking.
Don’t take imipramine if you are taking the following drugs: KlorCon (potassium phosphate) Drugs for bowel preparation, like potassium phosphate or potassium citrate Flumazenil Drugs for irregular heartbeat like dronedarone, Norpace or Norpace CR (disopyramide), and procainamide Parnate (tranylcypromine) Zyvox (linezolid) Emsam (selegiline transdermal) Like most TCAs, imipramine interacts with many drugs, so please discuss any concerns with your doctor or pharmacist before taking it.
Other drugs that interact with imipramine include: Cordarone, Nexterone, or Pacerone (amiodarone) Drugs for irregular heartbeat, like Tikosyn (dofetilide), dobutamine, and Betapace or Betapace AF ( sotalol ) Tagamet (cimetidine) Ephedra and ephedrine Epi-Pen, Epi-Pen, Jr.
( epinephrine ) Methadose and Dolophine (methadone) Biaxin (clarithromycin) Tofranil and Alcohol Impramine and alcohol can both cause dry mouth, dry eyes, dizziness, and confusion.
Tofranil (for example, sold as Tofranil and Tolerade) is the name of the most commonly used agent.

  • Read full chapter Psychopharmacology in the Medical Setting Jonathan R. Stevens M.D., M.P.H.,. Jonathan E. Alpert M.D., Ph.D., in Massachusetts General Hospital Handbook of General Hospital Psychiatry (Sixth Edition), 2011 Carbamazepine and Oxcarbazepine Carbamazepine is an iminostilbene anticonvulsant structurally related to the TCA imipramine.
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  • In fact, It seemed every medication I tried only made my symptoms (depression, panic attacks, spaciness, memory lapses, vertigo, fatigue, and frightening gist symptoms) much worse, especially the imipramine, which I had to fondle two separate blow for 6 weeks.
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