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Sinequan is the generic form of the brand-name drug Silenor, a prescription medication used to treat anxiety and depression.
It’s also used to treat insomnia (trouble with sleeping).
Sinequan belongs to a group of drugs called tricyclic antidepressants, which increase the brain’s levels of serotonin and norepinephrine, two chemicals known as neurotransmitters that relay messages in the brain.
Sinequan Warnings You should not take doxepin if you have glaucoma or problems with urination.
Sinequan is safe for elderly people, but there may be an increased risk of confusion or drowsiness.
Dosing may also differ due to decreased kidney function or heart problems.
Sinequan is not approved for use in children under age 12.
Do not use if you are allergic to doxepin or to similar medications such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).
Do not use doxepin if you have taken a monoamine oxidase inhibitor (MAOI) in the past 14 days.
A dangerous drug interaction could occur.
MAOIs include: Furazolidone (Furoxone) Isocarboxazid (Marplan) Linezolid (Zyvox) Phenelzine (Nardil) Rasagiline (Azilect) Selegiline (Emsam) Tranylcypromine (Parnate) Report any new or worsening symptoms to your doctor, including: Behavior or mood changes, such as feeling impulsive, irritable, agitated, hostile, aggressive, or restless Anxiety Panic attacks Trouble sleeping Increased depression Suicidal thoughts or thoughts of harming yourself Hyperactivity (mental or physical) To make sure doxepin is safe for you, tell your doctor if you have: Sleep apnea (breathing stops during sleep) Diabetes (doxepin may raise or lower blood sugar) Bipolar disorder (manic-depression) Some children, teenagers, and young adults have thoughts of suicide when first taking an antidepressant.
Your doctor will need to check your progress at regular visits while you are using doxepin.
Your family or other caregivers should also be alert to changes in your mood or symptoms.
Sinequan and Pregnancy It’s not known whether doxepin will harm an unborn baby.
Tell your doctor if you are pregnant or might become pregnant while using this medication.
Sinequan is excreted into human breast milk in small amounts.
In some embodiments, propofol prodrug may be administered prior or subsequent to administration of another therapeutic agent, such as for example, a compound for treating alcohol withdrawal, central pain, anxiety, or pruritus. When a propofol prodrug is administered concurrently with another therapeutic agent that potentially can produce adverse side effects including, but not limited to, toxicity, the therapeutic agent may be administered at a dose that falls below the threshold at which the adverse side effect is elicited. In certain embodiments of combination therapy, the combination therapy comprises alternating between administering a propofol prodrug and a composition comprising another therapeutic agent, e.g., to minimize adverse side effects associated with a particular drug. Compounds useful for treating central pain include tricyclic antidepressants such as amitriptyline; antiepileptic drugs such as lamotrigine, gabapentin, and baclofen; ketamine; midazolam; lidocaine; clonidine; and opioids such as morphine. Examples of useful compounds for treating anxiety disorders include anxiety disorders include alprazolam, atenolol, busipirone, chlordiazepoxide, clonidine, clorazepate, diazepam, doxepin, escitalopram, halazepam, hydroxyzine, lorazepam, nadolol, oxazepam, paroxetine, prochlorperazine, trifluoperazine, venlafaxine, amitriptyline, sertraline, citalopram, clomipramine, fluoxetine, fluvoxamine, and paroxetine. UV light therapy, cutaneous field stimulation, herbal remedies, nutritional remedies, reflex therapy, acupuncture, and hydrotherapy have also been shown to be effective to some extent in treating pruritis. It will be apparent to those skilled in the art that many modifications, both to materials and methods, may be practiced without departing from the scope of the disclosure. Animals were conscious at the time of the experiment.
Dilute the concentrate in four ounces (120 mL) of water; whole or skim milk; or orange, grapefruit, tomato, prune, or pineapple juice just before taking it. Histamine H 1 receptor antagonists such as cetirizine (Zyrtec) are the safest pharmacologic treatment for postburn pruritus. 46 Topical doxepin, a tricyclic antidepressant with potent antihistamine properties, reduces postburn pruritus and erythema. 47, 48 Small studies have shown that pulsed dye laser treatment is effective for postburn pruritus 46, 49; however, more research is necessary. Distomatosis 345. Sinequane-induced Immune Hemolytic Anemia 346.
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