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Sumatriptan is a medication used for the treatment of migraine headaches.
It is a synthetic drug belonging to the triptan class. Structurally, it is an analog of psilocybin, and features an N-methyl sulfonamidomethyl group at position C-5 on the indole ring.
Sumatriptan is produced and marketed by various drug manufacturers with many different trade names such as Imitrex, Imigran, Sumatran, Sumatriptanum, and Sumax, also as Treximet as an oral combination product with naproxen sodium.
Contents
1 Medical uses
2 Adverse effects
3 Mechanism of action
4 Pharmacokinetics
5 Approval
5.1 Generics
6 See also
7 References
Medical uses
Sumatriptan is effective for ending or relieving the intensity of migraine and cluster headaches.
Adverse effects
Overdose of sumatriptan can cause sulfhemoglobinemia, a rare condition in which the blood changes from red to green, due to the integration of sulfur into the hemoglobin molecule. If sumatriptan is discontinued, the condition reverses within a few weeks.
Serious cardiac events, including some that have been fatal, have occurred following the use of sumatriptan injection or tablets. Events reported have included coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, and ventricular fibrillation (V-Fib).
The most common side effects reported by at least 2% of patients in controlled trials of sumatriptan (25-, 50-, and 100-mg tablets) for migraine are atypical sensations (paresthesias and warm/cold sensations) reported by 4% in the placebo group and 5–6% in the sumatriptan groups, pain and other pressure sensations (including chest pain) reported by 4% in the placebo group and 6–8% in the sumatriptan groups, neurological events ( vertigo ) reported by less than 1% in the placebo group and less than 1% to 2% in the sumatriptan groups. Malaise/fatigue occurred in less than 1% of the placebo group and 2–3% of the sumatriptan groups. Sleep disturbance occurred in less than 1% in the placebo group to 2% in the sumatriptan group.
Mechanism of action
Sumatriptan is structurally similar to serotonin (5-HT), and is a 5-HT receptor (types 5-HT 1D and 5-HT 1B
Sumatriptan is also shown to decrease the activity of the trigeminal nerve, which presumably accounts for sumatriptan’s efficacy in treating cluster headaches. The injectable form of the drug has been shown to abort a cluster headache within 30 minutes in 77% of cases.
Pharmacokinetics
Sumatriptan is administered in several forms: tablets, subcutaneous injection, and nasal spray. Oral administration (as the succinate salt) suffers from poor bioavailability, partly due to presystemic metabolism —some of it gets broken down in the stomach and bloodstream before it reaches the target arteries. A new rapid-release tablet formulation has the same bioavailability, but the maximum concentration is achieved on average 10–15 minutes earlier. When injected, sumatriptan is faster-acting (usually within 10 minutes), but the effect lasts for a shorter time. Sumatriptan is metabolised primarily by monoamine oxidase A into 2‐{5‐[(methylsulfamoyl)methyl]‐indole‐3‐yl}acetic acid which is then conjugated to glucuronic acid. These metabolites are excreted in the urine and bile. Only about 3% of the active drug may be recovered unchanged.
There is no simple, direct relationship between sumatriptan concentration (pharmacokinetics) per se in the blood and its anti-migraine effect (pharmacodynamics). This paradox has, to some extent, been resolved by comparing the rates of absorption of the various sumatriptan formulations, rather than the absolute amounts of drug that they deliver.
Approval
Sumatriptan was the first clinically available triptan (in 1991). In the United States, it is available only by medical prescription (and is frequently limited, without prior authorization, to a quantity of nine in a 30-day period). This requirement for a medical prescription also exists in Australia. Several dosage forms for sumatriptan have been approved, including tablets, solution for injection, and nasal inhalers.
On April 15, 2008, the US FDA approved Treximet, a combination of sumatriptan and naproxen, an NSAID.
In July 2009, the US FDA approved a single-use jet injector formulation of sumatriptan. The device delivers a subcutaneous injection of 6 mg sumatriptan, without the use of a needle. Autoinjectors with needles have been previously available in Europe and North America for several years.
Phase III studies with a iontophoretic transdermal patch (Zelrix/Zecuity) started in July 2008.
Generics
Sumatriptan vials
On November 6, 2008, Par Pharmaceutical announced that it would begin shipping generic versions of sumatriptan injection (sumatriptan succinate injection) 4- and 6-mg starter kits and 4- and 6-mg filled syringe cartridges to the trade immediately. In addition, Par anticipates launching the 6-mg vials early in 2009.
Mylan Laboratories Inc., Ranbaxy Laboratories, Sandoz (a subsidiary of Novartis ), Dr. Reddy’s Laboratories, and other companies have received FDA approval for generic versions of sumatriptan tablets in 25-, 50-, and 100-mg doses since 2009. The drug is generically available in U.S. and European markets, since Glaxo’s patent protections have expired in those jurisdictions. Nasal spray sumatriptan is also generically available.
See also
Almotriptan
Avitriptan
Eletriptan
Naratriptan
Rizatriptan
Zolmitriptan

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