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Latanoprost, sold under the brand name Xalatan among others, is a medication used to treat increased pressure inside the eye.
Common side effects include blurry vision, redness of the eye, itchiness, and darkening of the iris.
Latanoprost approved for medical use in the United States in 1996.
1 Medical uses
1.1 Open-angle glaucoma
1.2 Closed-angle glaucoma
2 Adverse effects
2.1 Pregnancy
3 Interactions
4 Pharmacology
4.1 Mechanism of action
4.2 Pharmacokinetics
5 Chemistry
5.1 Stability
6 Society and culture
7 References
8 External links
Medical uses
Open-angle glaucoma
In people with ocular hypertension including open-angle glaucoma (IOP ≥21  mm Hg ), treatment with latanoprost reduced IOP levels by 22 to 39% over 1 to 12 months’ treatment. Latanoprost was more effective than timolol 0.5% twice daily in 3 of 4 large (n = 163 to 267) randomised, double-blind trials. Latanoprost demonstrated a stable long-term IOP-lowering effect in 1- or 2-year continuations of these trials, with no sign of diminishing effect during prolonged treatment.
Meta-analysis suggests that latanoprost is more effective than timolol in lowering IOP. However, it often causes iris pigmentation. While current evidence suggests that this pigmentation is benign, careful lifetime evaluation of patients is still justified.
Closed-angle glaucoma
Patients who had elevated IOP despite iridotomy and/or iridectomy (including patients of Asian descent), latanoprost was significantly more effective than timolol in two double-blind, monotherapy trials (8.2 and 8.8 mm Hg vs 5.2 and 5.7 mm Hg for latanoprost vs timolol at 12 and 2 weeks, respectively).
Adverse effects
Listed from most to least common:
> 5–15%: blurred vision, burning and stinging, conjunctival hyperemia, foreign body sensation, itching, increased (brown) pigmentation of the iris (causing heterochromia ), lengthening and thickening of the eyelashes (used, like bimatoprost, in the cosmetic industry as eyelash growth enhancers), punctate epithelial keratopathy
4%: cold or upper respiratory tract infections, flu-like syndrome
1–4%: dry eyes, excessive tearing, eye pain, lid crusting, lid edema, lid erythema (hyperemia), lid pain, photophobia
1–2%: chest pain, allergic skin reactions, arthralgia, back pain, myalgia

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