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Betamethasone is a steroid medication.
Serious side effects include an increased risk of infection, muscle weakness, severe allergic reactions, and psychosis.
Betamethasone was approved for medical use in the United States in 1961.
1 Medical uses
2 Side effects
3 Forms
4 See also
5 References
6 External links
Medical uses
Betamethasone is a corticosteroid that is available as pill, by injection, and as a cream.
It is used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination calcipotriol/betamethasone dipropionate. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids. Many betamethasone-based pharmaceuticals include the steroid as the valerate ester.
In a randomized controlled trial betamethasone was shown to reduce some of the ataxia symptoms associated with ataxia telangiectasia (A-T) by 28-31%.
Betamethasone is also used to stimulate fetal lung maturation ( to prevent IRDS ), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.
A cream with 0.05% betamethasone appears effective in treating phimosis in boys,
Side effects
Adrenal suppression
Groupings of fine blood vessels becoming prominent under the skin, petechiae
Excessive hair growth ( hypertrichosis )
Prolonged use of this medicine on extensive areas of skin, broken or raw skin, skin folds, or underneath airtight dressings may on rare occasions result in enough corticosteroid being absorbed to have side effects on other parts of the body; for example, by causing a decrease in the production of natural hormones by the adrenal glands.
Betamethasone is also used prior to delivery of a preterm baby to help prepare the lungs for breathing. However, because betamethasone crosses the placenta, which is required for its beneficial effects, it may also be associated with complications, such as hypoglycemia and leukocytosis in newborns exposed in utero.
When injected into the epidural space or the spine, it may cause serious side effects like loss of vision, stroke, and paralysis.
Betamethasone is available in a number of compound forms: betamethasone dipropionate (branded as Diprosone, Diprolene, Celestamine, Procort (in Pakistan), and others), betamethasone sodium phosphate (branded as Bentelan in Italy) and betamethasone valerate (branded as Audavate, Betnovate, Celestone, Fucibet, and others). In the United States and Canada, betamethasone is mixed with clotrimazole and sold as Lotrisone and Lotriderm. It is also available in combination with salicylic acid (branded as Diprosalic) for using in psoriatic skin conditions. In Mexico it is also sold mixed with both clotrimazole and gentamicin to add an antibacterial agent to the mix.
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