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Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012
Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina.
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Avanafil can be synthesized from a benzylamine derivative and a pyrimidine derivative:
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