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Anastrozole, sold under the brand name Arimidex among others, is a medication used in addition to other treatments for breast cancer.
Common side effects include hot flushes, altered mood, joint pain, and nausea.
Anastrozole was patented in 1987 and approved for medical use in 1995.
Mechanism
Anastrozole works by reversibly binding to the aromatase enzyme, and through competitive inhibition blocks the conversion of androgens to estrogens in peripheral (extragonadal) tissues.
Research
The ATAC trial was of localized breast cancer and women received either anastrozole, tamoxifen, or both for five years, followed by five years of follow-up.

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