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Additional information about the drug Nexium

Nexium is a prescription medication used to treat gastroesophageal reflux disease, or GERD. It is also used to heal acid-related damage to the lining of the esophagus, and to prevent ulcers caused by NSAIDs and H. Pylori bacteria. Nexium belongs to a group of drugs called proton pump inhibitors. These work by decreasing the amount of acid produced in the stomach.
This medication is available as delayed capsules and as packets for preparation of delayed-release oral suspensions. The oral forms are usually taken once a day, at least one hour before a meal.
Nexium is also available in an injectable for to be given directly into a vein (IV) by a healthcare provider, usually once daily.
Common side effects include headache, diarrhea, and nausea.
CYP2C19 is an enzyme in the blood that is responsible for breaking down esomeprazole and other drugs in the body. Some patients have less of this protein in their bodies, affecting how much of the drug gets eliminated. Levels of CYP2C19 can vary greatly between individuals, and those having less of this protein are known as “poor metabolizers.” 
CYP2C19 testing is done to determine whether you are a poor metabolizer. If you are a poor metabolizer, the levels of esomeprazole in your blood can become too high. As a result you may be at an increased risk of having more side effects from esomeprazole. 
Your doctor may adjust your dose of esomeprazole if you are a poor metabolizer.
Nexium is a prescription medication used to treat the symptoms of gastroesophageal reflux disease (GERD). Nexium may also be prescribed to heal acid-related damage to the lining of the esophagus (erosive esophagitis), and to help continue this healing. Nexium is also used to prevent ulcers caused by NSAIDs and H. Pylori bacteria, and for Zollinger-Ellison syndrome.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Nexium may be found in some form under the following brand names:
Nexium is part of the drug class:
Nexium can cause serious side effects. See the “Esomprazole Precautions” section.
Common side effects of esomeprazole include:
People who are taking multiple daily doses of proton pump inhibitor medicines for a long period of time may have an increased risk of fractures of the hip, wrist or spine.
Using esomeprazole for a long period of time may increase the risk of inflammation to your stomach lining. You may or may not have symptoms. Tell your doctor if you have stomach pain, nausea, vomiting, or weight loss.
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  • In 2009, the FDA warned against combining Plavix with acid-reducing products like esomeprazole ( Nexium) or omeprazole ( Prilosec) since they could substantially reduce the medication’s effectiveness because they inhibit the enzyme CYP 2C19, which activates Plavix.
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