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Linezolid is a prescription medication used to treat infections, including pneumonia, and certain blood and skin infections. Linezolid belongs to a group of antibiotics called oxazolidinones. It works by preventing bacteria from making proteins, which inhibits bacterial growth.
This medication comes in capsule, liquid, and an injectable (IV) form. The capsule and liquid forms can be taken with or without food.
Common side effects of linezolid include diarrhea, headache, nausea, and vomiting.
Linezolid is a prescription medication used to treat infections, including pneumonia, and certain blood and skin infections. 
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Linezolid may be found in some form under the following brand names:
Linezolid is part of the drug class:
Serious side effects have been reported with linezolid. See the “Drug Precautions” section.
Common side effects of linezolid include the following:
This is not a complete list of linezolid side effects. Ask your doctor or pharmacist for more information.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
This is not a complete list of linezolid drug interactions. Ask your doctor or pharmacist for more information.
Serious side effects have been reported with linezolid including the following:
Linezolid oral liquid contains phenylalanine. If you have phenylketonuria, the amount of phenylalanine you consume must be limited. Talk to your doctor about the other linezolid formulations available.
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of linezolid you should avoid eating or drinking large amounts of foods and beverages containing tyramine.
Tyramine is a naturally occurring compound found in some cheeses and other foods that may cause dangerously high blood pressure in people taking monoamine oxidase inhibitors (MAOIs) like linezolid.
You should avoid eating very large amounts of foods containing high amounts of tyramine such as:
Some of the signs and symptoms of dangerously high blood pressure (hypertensive crisis) are:
Get emergency medical help if you experience these symptoms.
Tell your doctor about all of your medical conditions including if you have:
Tell your doctor if you are pregnant or breastfeeding.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories – A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Linezolid falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.
It is not known if linezolid crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using linezolid.
Linezolid comes as a capsule, an oral liquid, and in an IV injection form. The capsules and oral liquid can be taken with or without food. It is usually taken twice daily (every 12 hours) for 10 to 28 days. Children 11 years of age and younger usually take linezolid two to three times a day (every 8 to 12 hours) for 10 to 28 days. The length of treatment depends on the type and severity of your infection.
Take linezolid exactly as prescribed. Do not skip linezolid doses. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing.
Do not stop taking linezolid before your doctor recommends, even if you are feeling better.
For adults, linezolid injection is infused into a vein twice daily for 10 to 28 days. The infusion usually lasts between 30 minutes and 2 hours. Children 11 years of age and younger usually receive Linezolid injections 2 to 3 times daily, for 10 to 28 days.
Injections are usually given by a healthcare professional in a medical facility, however, your doctor may decide that you can be taught to give yourself your injections.
The dose your doctor recommends will depend on your age, weight, and the type and severity of your infection.
If you take too much linezolid, call your local Poison Control Center or seek emergency medical attention right away.
If linezolid is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

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