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Famotidine, sold under the trade name Pepcid among others, is a histamine H 2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.
Unlike cimetidine, the first H 2 antagonist, famotidine has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other drugs.
It was discovered in 1979.
Contents
1 Medical uses
1.1 Preparations
2 Side effects
3 History
4 Research
5 See also
6 References
Medical uses
Relief of heartburn, acid indigestion, and sour stomach
Treatment for gastric and duodenal ulcers
Treatment for pathologic gastrointestinal hypersecretory conditions such as Zollinger–Ellison syndrome and multiple endocrine adenomas
Treatment for gastroesophageal reflux disease (GERD)
Treatment for esophagitis
Part of a multidrug regimen for Helicobacter pylori eradication, although omeprazole may be somewhat more effective.
Prevention of NSAID -induced peptic ulcers.
Given to surgery patients before operations to reduce the risk of aspiration pneumonitis.
Famotidine is also given to dogs and cats with acid reflux.
Preparations
Certain preparations of famotidine are available over the counter (OTC) in various countries. In the United States and Canada, 10 mg and 20 mg tablets, sometimes in combination with an antacid, are available OTC. Larger doses still require a medical prescription.
Formulations of famotidine in combination with ibuprofen were marketed by Horizon Pharma under the trade name Duexis.
Side effects
Side effects associated with famotidine use include headache, dizziness, and constipation or diarrhea.
History
Famotidine was developed by Yamanouchi Pharmaceutical Co.
It was first marketed in 1981. Pepcid RPD orally disintegrating tablets were released in 1999. Generic preparations became available in 2001, e.g. Fluxid ( Schwarz ) or Quamatel ( Gedeon Richter Ltd. ).
In the United States and Canada, a product called Pepcid Complete, which combines famotidine with an antacid in a chewable tablet to quickly relieve the symptoms of excess stomach acid, is available. In the UK, this product was known as Pepcidtwo prior to its discontinuation in April 2015.
Famotidine suffers from poor bioavailability (50%), as it is poorly soluble in the low pH of the stomach. When used in combination with antacids, it promotes local delivery of these drugs to the receptor of the parietal cell wall. Therefore, researchers are developing innovative formulations of tablets, such as gastroretentive drug delivery systems. Such tablets are retained in the stomach for a longer period of time, thereby improving the bioavailability of drugs. Local delivery also increases bioavailability at the stomach wall receptor site and increases the efficacy of drugs to reduce acid secretion.
Research
Famotidine has been investigated as an adjunct in treatment-resistant schizophrenia. In one trial, it caused a 10% reduction in schizophrenic symptom severity in treatment-resistant patients.
See also
Ranitidine, another popular H 2 receptor antagonist
Nizatidine

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