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Clonidine is a medication that is used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, tic disorders, withdrawal (from either alcohol, opioids, or smoking ), migraine, menopausal flushing, diarrhea, and certain pain conditions. It is marketed under many brand names.
The adverse effects include sedation, dry mouth, and low blood pressure.
Clonidine treats high blood pressure by stimulating α 2 receptors in the brain stem, which decreases peripheral vascular resistance, lowering blood pressure. Clonidine also may cause bradycardia, probably by increasing signaling through the vagus nerve. When given intravenously, clonidine temporarily increases blood pressure by stimulating postsynaptic α 2 receptors in smooth muscle in the lining of blood vessels. This does not occur when clonidine is given by mouth or transdermally. : 201–203
It has been in use as a medication since 1966.
1 Medical uses
1.1 Clonidine suppression test
1.2 Pregnancy
2 Adverse effects
2.1 Withdrawal
3 Pharmacology
3.1 Mechanism of action
3.1.1 High blood pressure
3.1.2 Attention deficit hyperactivity disorder
3.1.3 Growth hormone test
3.2 Pharmacokinetics
4 Brand names
5 References
6 External links
Medical uses
Clonidine tablets and transdermal patch
Clonidine was introduced in 1966.
Clonidine may be used to ease withdrawal symptoms associated with the long-term use of narcotics, alcohol, benzodiazepines and nicotine (smoking).
Clonidine also has several off-label uses, and has been prescribed to treat psychiatric disorders including stress, sleep disorders, and hyperarousal caused by post-traumatic stress disorder, borderline personality disorder, and other anxiety disorders.
Clonidine suppression test
The reduction in circulating norepinephrine by clonidine was used in the past as an investigatory test for phaeochromocytoma, which is a catecholamine-synthesizing tumour, usually found in the adrenal medulla.
Clonidine is classed by the FDA as pregnancy category C. It is classified by the TGA of Australia as pregnancy category B3, which means that it has shown some detrimental effects on fetal development in animal studies, although the relevance of this to human beings is unknown.
Adverse effects
The principal adverse effects of clonidine are sedation, dry mouth, and hypotension (low blood pressure).
Adverse effects by frequency
Very common (>10% frequency):
Orthostatic hypotension
Somnolence (dose-dependent)
Xerostomia (dry mouth)
Headache (dose-dependent)
Skin reactions (if given transdermally)
Common (1-10% frequency):
Sedation (dose-dependent)
Abnormal LFTs
Weight gain/loss
Pain below the ear (from salivary gland)
Erectile dysfunction
Uncommon (0.1-1% frequency):
Delusional perception
Sinus bradycardia
Raynaud’s phenomenon
Rare (

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