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Clarithromycin, sold under the brand name Biaxin among others, is an antibiotic used to treat various bacterial infections.
Common side effects include nausea, vomiting, headaches, and diarrhea.
Clarithromycin was developed in 1980.
Contents
1 Medical uses
1.1 Spectrum of bacterial susceptibility
2 Contraindications
3 Side effects
3.1 Cardiac
3.2 Liver and kidney
3.3 Central nervous system
3.4 Infection
3.5 Pregnancy and breastfeeding
4 Interactions
4.1 Colchicine
4.2 Statins
4.3 Calcium channel blockers
4.4 Carbamazepine
4.5 HIV medications
5 Mechanism of action
6 Pharmacokinetics
7 Metabolism
8 History
9 Society and culture
9.1 Cost
9.2 Available forms
9.3 Brand names
9.4 Manufacturers
10 References
11 External links
Medical uses
Clarithromycin is primarily used to treat a number of bacterial infections including pneumonia, Helicobacter pylori, and as an alternative to penicillin in strep throat. It is effective against upper and lower respiratory tract infections, skin and soft tissue infections and helicobacter pylori infections associated with duodenal ulcers.
Spectrum of bacterial susceptibility
This section needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (February 2018) ( Learn how and when to remove this template message )
Aerobic Gram-positive bacteria
Staphylococcus aureus
Streptococcus pneumoniae
Streptococcus pyogenes
Aerobic Gram-negative bacteria
Haemophilus parainfluenzae 
Haemophilus influenzae
Moraxella catarrhalis
Helicobacter
Helicobacter pylori
Mycobacteria
Mycobacterium avium complex consisting of:
Mycobacterium avium avium
Mycobacterium intracellulare
Other bacteria
Chlamydia pneumoniae
Mycoplasma pneumoniae
Safety and effectiveness of clarithromycin in treating clinical infections due to the following bacteria have not been established in adequate and well-controlled clinical trials:
Aerobic Gram-positive bacteria
Streptococcus agalactiae
Streptococcus (Groups C, F, G)
Viridans group streptococci
Aerobic Gram-negative bacteria
Bordetella pertussis
Legionella pneumophila
Pasteurella multocida
Anaerobic Gram-positive bacteria
Clostridium perfringens
Peptococcus Niger
Propionibacterium acnes
Anaerobic Gram-negative bacteria
Prevotella melaninogenica (formerly Bacteroides melaninogenicus )
Contraindications
Clarithromycin should not be taken by people who are allergic to other macrolides or inactive ingredients in the tablets, including microcrystalline cellulose, croscarmelose sodium, magnesium stearate, and povidone
Clarithromycin should not be used by people with a history of cholestatic jaundice and/or liver dysfunction associated with prior clarithromycin use.
Clarithromycin should not be used in the setting of hypokalaemia (low blood potassium)
Use of clarithromycin with the following medications: cisapride, pimozide, astemizole, terfenadine, ergotamine, ticagrelor, ranolazine or dihydroergotamine is not recommended.
It should not be used with colchicine in people with kidney or liver impairment.
Concomitant use with cholesterol medications such as lovastatin or simvastatin.
Hypersensitivity to clarithromycin or any component of the product, erythromycin, or any macrolide antibiotics.
QT prolongation or ventricular cardiac arrhythmias, including torsade de pointes.
Side effects
The most common side effects are gastrointestinal: diarrhea (3%), nausea (3%), abdominal pain (3%), and vomiting (6%). It also can cause headaches, insomnia, and abnormal liver function tests. Allergic reactions include rashes and anaphylaxis. Less common side effects (

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