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Dimenhydrinate, marketed as Dramamine and Gravol among others, is an over-the-counter medication used to treat motion sickness and nausea. Dimenhydrinate is a combination, or a salt of two drugs: diphenhydramine and 8-chlorotheophylline.
It is most commonly prepared as tablets, although it is also available in liquid form and as a suppository.
1 Medical uses
2 Recreational use
3 Veterinary use
4 Brand names
6 External links
Dimenhydrinate is primarily used to treat nausea, vomiting, and dizziness caused by motion sickness. Dimenhydrinate has also been found to aid in the treatment of ear congestion.
Diphenhydramine is the primary constituent of dimenhydrinate and dictates the primary effect. The main difference relative to pure diphenhydramine is a lower potency due to being combined with 8-chlorotheophylline. By weight, dimenhydrinate is between 53% to 55.5% diphenhydramine.
8-Chlorotheophylline, a chlorinated derivative of theophylline, was added in order to counteract drowsiness. Theophylline is very closely related to caffeine and theobromine, mild central nervous system stimulants. It was thought by scientists
Dimenhydrinate is recreationally used as a deliriant.
Many users report a side effect profile consistent with tropane alkaloid (e.g. atropine ) poisoning as both show antagonism of muscarinic acetylcholine receptors in both the central and autonomic nervous system, which inhibits various signal transduction pathways. In the CNS, diphenhydramine readily crosses the blood-brain barrier, exerting effects within the visual and auditory cortex.
Other CNS effects occur within the limbic system and hippocampus, causing confusion and temporary amnesia due to decreased acetylcholine signaling. Toxicology also manifests in the autonomic nervous system, primarily at the neuromuscular junction, resulting in ataxia and extrapyramidal side-effects and the feeling of heaviness in the legs, and at sympathetic post-ganglionic junctions, causing urinary retention, pupil dilation, tachycardia, irregular urination, and dry red skin caused by decreased exocrine gland secretions, and mucous membranes. Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular dysrhythmias, coma and death. Such a side-effect profile is thought to give ethanolamine -class antihistamines a relatively low abuse liability. The specific antidote for dimenhydrinate poisoning is physostigmine, usually given by IV in a hospital.
Dimenhydrinate has successfully been used as an antiemetic and sedative in housepets.
Dimenhydrinate is marketed under many brand names: in the USA, Mexico and Serbia as Dramamine, in Ukraine as Driminate, in India and Canada as Gravol, in Iceland as Gravamin, in Russia and Croatia as Dramina, in South Africa and Germany as Vomex, in Australia and Austria as Vertirosan, in Brazil as Dramin, in Ecuador as Anautin, in Hungary as Daedalon, in Sweden as Calma or Arlevert,
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