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Additional information about the drug Cordarone

Cordarone, sold under the brand names Cordarone, Nexterone or Pacerone, is a medication used — sometimes in emergency situations — to treat irregular heartbeats ( arrhythmias ).
Heart arrhythmias can occur in conditions such as ventricular arrhythmias, atrial fibrillation, or hypertrophic cardiomyopathy (thickening of the walls of the heart).
Cordarone may also be prescribed off-label for children to help treat irregular heartbeat.
Cordarone belongs to group of drugs known as anti-arrhythmics.
There are four major classes of anti-arrhythmics, and amiodarone belongs to Class III.
It works by: Blocking receptors that use adrenaline Slowing or preventing the passing of sodium out of heart cells Decreasing the electrical activity in the heart Increasing the activity time for contraction in the heart Cordarone was originally approved by the Food and Drug Administration (FDA) under the brand name Pacerone in 1985, and was manufactured by Wyeth Pharmaceuticals (now a division of Pfizer).
Cordarone Warnings Cordarone has two black-box warnings for having the potential to cause the risk of sudden death and potentially deadly side effects including: Lung damage, including fibrosis (scarring) or inflammation of the lungs Liver damage or inflammation, including causing abnormal levels of liver function tests (LFTs) Irregular heartbeat or heart rhythm.
(Note that medications that are taken for arrhythmias can also cause arrhythmias.) As a result, amiodarone is only prescribed for patients in situations where the risk outweighs the benefit (e.g., for patients who have heart conditions that are considered to be deadly).
You should not take amiodarone if: You are allergic to amiodarone or any of the inactive ingredients Have severe abnormal function of the sinus node or 2/3 sinus block Patients who receive amiodarone via injection (intravenously) will need to do so in a hospital setting.
Talk to your doctor before taking amiodarone if you: Are sensitive to sunlight Have thyroid conditions Have a pacemaker Have heart disease or heart conditions, including heart block, slow heartbeat, enlarged heart, and/or low blood pressure Are taking warfarin (amiodarone can increase risk of bleeding) Have an existing lung disease such as pulmonary fibrosis or chronic obstructive pulmonary disease (COPD) Pregnancy and Cordarone Cordarone should only be taken in situations when there are no other options available, because the drug could harm the fetus.
Regardless, you should tell your doctor if you are pregnant or might become pregnant before taking this medication.
Cordarone is not recommended for breastfeeding women, so make sure to tell your physician if you are breastfeeding or plan to breastfeed.
BasicDescription Back to Top Cordarone Side Effects Common Side Effects of Cordarone You should tell your doctor if any of the following side effects become severe or don’t go away: Low blood pressure Dizziness or headache Awkward stance and walking Memory loss Restlessness Shaking and uncontrollable movement Tiredness and trouble sleeping Sensitivity to the sun Low levels of thyroid hormone Increased cholesterol levels, including triglycerides and low-density lipoproteins (LDL) Loss of appetite Severe cough or shortness of breath with exertion (that wasn’t present before starting amiodarone) Serious Side Effects of Cordarone You should call your doctor immediately if you experience any of the following serious side effects: Congestive heart failure Slowed heart beat (bradycardia) Atrioventricular (AV) block or sinoatrial (SA) node block Overactive thyroid Inflammation of the liver, including lost liver function (cirrhosis) Problems with vision (seeing halos or yellowish colors) Blood disorders Inflammation of the pancreas Allergic reactions Nerve damage (when taken for long periods of time) Severe skin reactions Rare Side Effects of Cordarone: Although not common, some patients taking amiodarone may notice a bluish or gray-blue tint to the skin (ceruloderma).
In rare cases, patients who have taken amiodarone for long periods of time and in higher doses may begin to see yellowish halos due to a build-up of small bodies of fat on the eye, known as corneal microdeposits.
This side effect reportedly goes away roughly seven months after stopping amiodarone.
Another rare side effect is a condition known as demyelinating polyneuropathy, which can lead to partial or permanent blindness.
Both the pharmacokinetics and the electrophysiologic profile of amiodarone are complex, and its optimal and safe use requires careful patient surveillance with respect to potential adverse effects.

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