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Aldactone is the generic form of the brand-name drug Aldactone, a prescription diuretic drug.
The drug is used to treat a condition called primary hyperaldosteronism, in which the body produces excess amounts of the hormone aldosterone, which regulates your body’s sodium and water levels.
Aldactone helps restore a healthy balance of sodium and potassium in your body.
It’s also used to treat: Essential hypertension ( high blood pressure with an unknown cause) Hypokalemia (potassium deficiency) Edema (fluid retention) from various conditions, including congestive heart failure, kidney disease, and cirrhosis (liver scarring) Severe heart failure Aldactone is a potassium-sparing diuretic.
Sometimes called “water pills,” diuretics help the kidneys expel water and salt in urine while retaining potassium.
The drug may also be used in combination with other medications to treat precocious (early) puberty and myasthenia gravis, a neuromuscular disease.
Manufactured by Pfizer, spironolactone was approved by the Food and Drug Administration (FDA) in 1985.
Though spironolactone has been around for over 25 years, the FDA is still updating the drug’s safety labeling.
In 2011, the FDA added Stevens-Johnson syndrome and toxic epidermal necrolysis — two life-threatening skin disorders — to spironolactone’s list of possible side effects.
In 2013, the agency added a warning about a potentially fatal condition called hyperkalemia (high potassium levels in the blood).
Aldactone for Acne Aldactone is sometimes used off-label to treat women with persistent adult acne due to increased androgen levels, because the drug is able to inhibit the activity of sebaceous glands (small skin glands that releases an oily, lubricating substance called sebum).
The development of acne lesions is associated partly with increased sebum secretion, which can be stimulated in women by androgen excess.
Aldactone for Hair Loss and Hirsutism Because of its anti-androgen activity, spironolactone is also used off-label to treat female-pattern hair loss and hirsutism.
Women with certain endocrine disorders produce more androgens than normal, leading to hair loss on the top or front of the scalp, and increased hair on the face and other (generally hair-free) body areas.
Aldactone helps by slowing down the production, and blocking the action, of androgens.
Aldactone Warnings Aldactone carries a black-box warning for tumor risk, due to chronic toxicity studies that show spironolactone can cause tumor development in rats.
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