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Nimodipine (sold under the brandname Nimotop ) is a calcium channel blocker originally developed for the treatment of high blood pressure. It is not frequently used for this indication, but has shown good results in preventing a major complication of subarachnoid hemorrhage (a form of cerebral hemorrhage ) termed vasospasm ; this is now the main use of nimodipine.
Contents
1 Medical use
1.1 Dosage
2 Contraindications
3 Side-effects
4 Pharmacokinetics
4.1 Absorption
4.2 Metabolism
4.3 Excretion
5 Mode of action
6 Synthesis
6.1 Notes
7 Stereochemistry
8 References
9 External links
Medical use
Because it has some selectivity for cerebral vasculature, nimodipine’s main use is in the prevention of cerebral vasospasm and resultant ischemia, a complication of subarachnoid hemorrhage (a form of cerebral bleed ), specifically from ruptured intracranial berry aneurysms irrespective of the patient’s post-ictus neurological condition.
A 2003 trial (Belfort et al. ) found nimodipine was inferior to magnesium sulfate in preventing seizures in women with severe preeclampsia.
Nimodipine is not regularly used to treat head injury. Several investigations have been performed evaluating its use for traumatic subarachnoid hemorrhage; a systematic review of 4 trials did not suggest any significant benefit to the patients that receive nimodipine therapy.
Dosage
The regular dosage is 60 mg tablets every four hours. If the patient is unable to take tablets orally, it was previously given via intravenous infusion at a rate of 1–2 mg/hour (lower dosage if the body weight is

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