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Additional information about the drug Levaquin

Levaquin is the brand name for levofloxacin, a prescription antibiotic drug used to treat a variety of bacterial infections, such as: Pneumonia Acute bacterial sinusitis Chronic bronchitis worsened by bacterial infections Skin infections Chronic prostate gland infection (prostatitis) Urinary tract infection (UTI) Acute kidney infection Inhalational anthrax, or anthrax contracted by breathing in anthrax spores Pneumonic and septicemic plague (Levaquin is also used to prevent contracting plague ) Levaquin belongs to a class of antibacterial agents called fluoroquinolones, which kill bacteria by inhibiting the activity of certain enzymes bacteria require to replicate, transcribe, repair, and recombine DNA.
Doctors may also prescribe Levaquin “off-label” to treat or prevent other bacterial infections, including tuberculosis (TB), Salmonella food poisoning, Shigella food poisoning, Campylobacter infections, and disseminated Mycobacterium avium complex disease, especially for people with a weakened immune system from HIV or other conditions.
Levaquin was first approved by the Food and Drug Administration (FDA) in 1996, and is produced by Janssen Pharmaceuticals, Inc, a subsidiary of Johnson & Johnson.
Levaquin and Tendon Issues In 2008, the FDA required all fluoroquinolone manufacturers to include a black-box warning that the drug class can increase a person’s risk of tendonitis (tendon inflammation) and tendon rupture, a decision that came too late for a lot of people taking Levaquin, resulting in numerous lawsuits.
Plaintiffs charge that Johnson & Johnson should have strengthened their warnings about the potential tendon issues associated with Levaquin before the FDA issued its decree, and also that the company downplayed the drug’s risks to boost sales.
In 2010, Johnson & Johnson lost a court case against 87-year-old John Schedin, and had to pay nearly $2 million to Schedin for the damage he received to his Achilles tendon after taking Levaquin.
The company subsequently won several other court cases, in which plaintiffs failed to show the drug caused their tendon issues.
To date, however, thousands more cases have reached settlements out of court.
The risk of tendonitis and tendon ruptures is greater for people over 60 years old, people taking corticosteroid drugs, and people with kidney, heart, or lung transplants.
Physical activity or exercise, kidney failure, and having previous tendon problems, such as rheumatoid arthritis, can also increase your risk of tendon issues while taking Levaquin.
Levaquin Warnings You should not take Levaquin if you have a known sensitivity or allergy to levofloxacin and other quinolones (the family of antibiotics that encompasses fluoroquinolones).
You should also avoid the drug if you have the neuromuscular disease myasthenia gravis, as the drug could worsen your muscle weakness.
Some people experience other serious and sometimes life-threatening reactions from taking Levaquin, such as: Dangerous skin disorders, including toxic epidermal necrolysis and Stevens- Johnson Syndrome Blood vessel inflammation, joint pain, and muscle pain Allergic pneumonitis, an inflammation of the walls of the lung’s air sacs Interstitial nephritis (a kidney disorder) and kidney failure Hepatitis (liver inflammation), jaundice (yellowing of the skin and eyes), liver cell death, and liver failure Blood-related issues, including deficiencies in red blood cells or white blood cells Pregnancy and Levaquin It’s unknown if Levaquin can harm a developing fetus because no adequate and well-controlled studies have been carried out in pregnant women.
However, the drug’s antimicrobial benefits to the mother may outweigh the potential risks to her unborn child.
Levaquin is presumed to be present in breast milk, and the drug has the potential to cause serious side effects in infants.
Breastfeeding mothers taking Levaquin should either discontinue the drug or stop breastfeeding.
Patients were considered improved when: PMNLs decreased to 3, no growth in previously positive culture cases, and improved clinical manifestations with at least 5 d of antibiotic therapy. Cefotaxime failed in 19% of patients; of these patients, 11 (100%) responded to meropenem and 6 (75%) responded to levofloxacin.Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis.Since then, cefotaxime has become the empiric antibiotic of choice for the treatment of SBP.

  • Clarithro Clarithromycin; Duration Length of treatment; G Grepafloxacin; Oflox Ofloxacin Levaquin: The efficacy of levofloxacin in the treatment of genitourinary tract infections has been the subject of a small number of trials ( Table 7.4 ). The results from two studies in which levofloxacin was used to treat acute pyelonephritis were combined and analyzed.
  • Initial therapy of acute pyelonephritis is usually with ciprofloxacin or levofloxacin, ceftriaxone, or gentamicin.
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