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Additional information about the drug Hydrea

Hydrea is a prescription drug sold under the brand name Hydrea.
It’s used to treat psoriasis, chronic myelogenous leukemia (a cancer of the white blood cells), ovarian cancer, melanoma (a form of skin cancer ), and certain head and neck cancers.
The medicine also helps people with sickle cell anemia (an inherited blood disorder) by reducing the frequency of painful sickle cell crisis episodes and the need for blood transfusions.
Additionally, hydroxyurea is sometimes used to treat polycythemia vera (a disorder of the bone marrow) by reducing the red blood cell mass.
Hydrea belongs to a class of drugs called antimetabolites.
It works by slowing or stopping the growth of cancer cells in the body, and by helping to prevent the formation of abnormal red blood cells.
The Food and Drug Administration (FDA) approved hydroxyurea in 1967.
It’s marketed by Bristol-Myers Squibb Company.
Hydrea Warnings Hydrea contains a black-box warning because it can cause a severe drop in the number of blood cells in your bone marrow.
This can increase your risk of a serious infection or bleeding.
Tell your doctor right away if you experience any of the following symptoms while taking hydroxyurea: Fever, sore throat, cough, congestion, or other signs of infection Unusual bruising or bleeding Vomit that’s bloody or looks like coffee grounds Bloody or black, tarry stools Try to avoid contact with people who have infections or colds while taking this drug.
Don’t receive any vaccinations while taking hydroxyurea without first talking to your doctor.
Hydrea also contains a black-box warning because the medicine may increase your chance of developing other cancers.
Some people have reported skin cancer or secondary leukemia after taking hydroxyurea.
Call your healthcare provider right away if you notice any of the following symptoms: Change in the appearance of a mole A new growth on the skin Any unusual skin changes Before taking hydroxyurea, tell your doctor if you have, or have had: Severe bone marrow depression Low white blood cell counts Low blood platelet levels Severe anemia or another blood disorder HIV/AIDS Kidney disease Liver disease Allergies to medicines Also, let your healthcare provider know if you’ve ever been treated with chemotherapy or radiation.
Tell your doctor you take hydroxyurea before having any type of surgery, including a dental procedure.
Randomized match of fluorouracil with an increment of cisplatin vs hydroxyurea as an adjunct to radiation analysis in manoeuvre IIB-IVA carcinoma of the cervix with negative paraaortic nodes: a Gynecologic Oncology League and Southwest Oncology Association study.

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  • Occasionally, patients describe gastrointestinal discomfort; when persistent, changing the daily dose from morning to evening may help reduce symptoms. Although uncommon, skin and nail pigmentation changes are cosmetic and rarely bothersome to patients or families. However, because treatment duration now approaches 12 to 15 years in some children and adolescents and cumulative patient-years worldwide probably number in the tens of thousands, major concerns about serious long-term consequences are starting to diminish at many academic programs. A national registry of patients on hydroxyurea would be very helpful to gauge the incidence of unusual adverse events but does not currently exist.
  • Editorial Policies Author Information Peer Review Guidelines Open Outlook Materials and methods: To further investigate the role of leukocytes in HbF expression in SCD, we examined the presence of HbF silencing factors in the serum of 82 SCD patients who received hydroxyurea (HU) therapy.
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