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Orlistat is a prescription and over the counter medication used for weight loss. Orlistat belongs to a group of drugs called lipase inhibitors, which work by preventing the absorption of fat in your body. 
Orlistat is a medicine used to help obese people lose weight and keep this weight off. Orlistat should be used together with a reduced-calorie diet that your doctor will recommend. 
Orlistat may be found in some form under the following brand names:
Orlistat is part of the drug class:
Because orlistat works by blocking the absorption of dietary fat, it is likely that you will experience some changes in bowel habits. These generally occur during the first weeks of treatment; however, they may continue throughout your use of orlistat. These changes may include
These bowel changes are a natural effect of blocking the fat from being absorbed and indicate that orlistat is working. They generally occur early in treatment, particularly after meals containing higher amounts of fat than are recommended. These symptoms are often temporary and may lessen or disappear as you continue treatment and keep to your recommended diet of meals containing no more than about 30% fat. However, these side effects may occur in some individuals over a period of 6 months or longer.
Be sure to discuss with your doctor all medications (including herbal products) you are currently taking, including medicines you can get without a prescription (over-the-counter), to determine if orlistat can be taken in addition to these medications.
You should not use orlistat if you:
Orlistat has been shown to reduce the absorption of certain vitamins. You should take a multivitamin containing vitamins D, E, K, and beta-carotene once a day at least 2 hours before or after the administration of orlistat, such as at bedtime.
Some patients taking orlistat may develop an increased risk for the development of kidney stones. Promptly report any symptoms of back pain or blood in the urine.
Some patients prescribed orlistat may already be at increased risk for the formation of gall stones. Weight loss with orlistat can increase the risk of gall stones. Promptly report any symptoms of pain in the upper right portion of the abdomen. The pain may be accompanied by nausea and vomiting.
There have been rare reports of severe liver injury in patients taking orlistat. Promptly discontinue orlistat and contact your healthcare provider if you develop symptoms suggestive of liver impairment, such as loss of appetite, itching, yellowing of the skin, dark urine, light colored stools, or right upper quadrant pain.
You should use orlistat together with a nutritionally balanced, mildly reduced-calorie diet that contains no more than about 30% of calories from fat.
Read all food labels and avoid foods that have more than 30% fat.
Before beginning treatment with orlistat, make sure your doctor knows if you are:
This information will help you and your physician decide if the expected advantages of orlistat are greater than any possible disadvantages.
Tell your doctor if you are pregnant or plan to become pregnant. Orlistat should not be used during pregnancy as it may harm your unborn baby.
Weight loss offers no potential benefit to a pregnant woman and may result in fetal harm. A minimum weight gain, and no weight loss, is currently recommended for all pregnant women, including those who are already overweight or obese, due to the obligatory weight gain that occurs in maternal tissues during pregnancy. 
Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if orlistat is excreted in human breast milk or if it will harm your nursing baby.
Take orlistat exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
The recommended dose is one 120 mg capsule by mouth with liquid at each main meal that contains fat. You can take orlistat in conjunction with a mildly reduced-calorie diet up to 3 times a day.
The recommended dose is one 60 mg capsule by mouth with liquid at each main meal that contains fat. You can take orlistat in conjunction with a mildly reduced-calorie diet up to 3 times a day.
If you take too much orlistat, call your local Poison Control Center or seek emergency medical attention right away.

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