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Ezetimibe is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol absorption in the small intestine. It may be used alone (marketed as Zetia or Ezetrol ), when other cholesterol-lowering medications are not tolerated, or together with statins (e.g., ezetimibe/simvastatin, marketed as Vytorin or Inegy ) when statins alone do not control cholesterol.
Ezetimibe is recommended as second line therapy for those intolerant of statins or unable to achieve target low-density lipoprotein (LDL) cholesterol levels on statins alone by several major medical group practice guidelines, including the American College of Cardiology. In the United States as of 2015 the 10 mg pill costs between 4.84 and 7.88 USD.
Contents
1 Medical uses
2 Contraindications
3 Adverse effects
4 Overdose
5 Mechanism of action
6 Pharmacokinetics
7 See also
8 References
Medical uses
As of mid-2014, treatment guidelines of the American Heart Association /American College of Cardiology recommend ezetimibe as one of several second line treatment options for people who are intolerant of statins or who are unable to reach serum LDL goals using statins alone.
While ezetimibe reduces LDL cholesterol, it has not been shown to affect outcomes such as risk of death or major cardiovascular event like heart attack or stroke.
Ezetimibe is indicated in the United States as an add-on to dietary measures to:
reduce levels of certain lipids in people with primary hyperlipidemia, alone or with a statin ;
reduce levels of certain lipids in people with mixed hyperlipidemia, in combination with fenofibrate ;
reduce levels of certain lipids in people with homozygous familial hypercholesterolemia, in combination with specific statins;
reduce levels of certain lipids in people with homozygous sitosterolemia.
Contraindications
The two contraindications to taking ezetimibe are a previous allergic reaction to ezetimibe, including symptoms of rash, angioedema, and anaphylaxis, and severe liver disease, especially when taken with a statin.
Ezetimibe may have significant medication interactions with cyclosporine and with fibrates other than fenofibrate.
Adverse effects
Common adverse drug reactions (≥1% of patients) associated with ezetimibe therapy include: headache and/or diarrhea (steatorrhea). Infrequent adverse effects (0.1–1% of patients) include: myalgia and/or raised liver function test ( ALT / AST ) results. Rarely (

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