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Additional information about the drug Clozaril

Clozaril is the generic form of the brand-name drug Clozaril, which is used to treat symptoms of schizophrenia.
Schizophrenia is a mental illness that’s characterized by disturbed thinking, unusual emotions, and hallucinations.
Clozaril is in a class of drugs known as atypical antipsychotics, and is used to treat schizophrenia or reduce the risk of suicidal behavior in people with schizophrenia or other mental health disorders.
Clozaril, manufactured by Novartis Pharmaceuticals, was first approved by the Food and Drug Administration (FDA) in 1989 for people with treatment-resistant schizophrenia.
Clozaril Black-Box Warnings Clozaril carries several black-box warnings, including one because it can lower your count of blood cells that help you fight infections.
Your doctor will order lab tests before, during, and after your treatment with this medicine.
You should call your doctor immediately if you experience any of the following symptoms while taking clozapine: Fever Sore throat Chills Sores in your mouth or throat Any other symptoms of flu or infection You can only obtain clozapine from a certified pharmacy under a special program.
You must be registered in the program and agree to undergo frequent blood tests.
This medicine also has a black-box warning because it may cause seizures.
You should tell your doctor if you have a history of seizures, head injuries, or brain tumors before taking clozapine.
Clozaril carries a black-box warning because it could cause a dangerous heart condition called myocarditis.
You should call your doctor immediately if you experience any of the following symptoms: Difficulty breathing or fast breathing Fast, irregular, or pounding heartbeat Chest pain Extreme fatigue This drug also has a black-box warning because of the potential risk of other heart or respiratory effects.
Studies have shown that older adults with dementia who take antipsychotics such as clozapine are at an increased risk of dying.
This medicine carries a black-box warning because of this risk, and it’s not approved by the FDA to treat older adults with dementia.
The drug may also cause lightheadedness, dizziness, or fainting when you stand.
Your doctor will likely start you on a low dose of clozapine and gradually increase it to lower your chance of experiencing this side effect.

  • Simple causes of chest pain such as gastro-oesophageal reflux disease are common in patients taking clozapine, however myocardial infarction, myocarditis and cardiomyopathy should be considered as differential diagnoses.
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