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Cabergoline (brand names Dostinex and others), an ergot derivative, is a potent dopamine receptor agonist on D 2 receptors. Rat studies show cabergoline has a direct inhibitory effect on pituitary lactotroph ( prolactin ) cells. It is frequently used as a first-line agent in the management of prolactinomas due to its higher affinity for D 2 receptor sites, less severe side effects, and more convenient dosing schedule than the older bromocriptine, though in pregnancy bromocripine is often still chosen since there is less data on safety in pregnancy for cabergoline.
Contents
1 Medical uses
1.1 Off-label
1.2 Pregnancy and lactation
2 Contraindications and precautions
3 Side effects
3.1 Valvular heart disease
4 Interactions
5 Pharmacology
5.1 Binding profile
6 Pharmacokinetics
7 Mechanism of action
8 Research
9 History
10 See also
11 References
12 External links
Medical uses
Lactation suppression
hyperprolactinemia
adjunctive therapy of prolactin-producing pituitary gland tumors ( prolactinomas );
monotherapy of Parkinson’s disease in the early phase;
combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-phase Parkinson’s disease;
in some countries also: ablactation and dysfunctions associated with hyperprolactinemia ( amenorrhea, oligomenorrhea, anovulation, nonpuerperal mastitis and galactorrhea );
treatment of uterine fibroids.
adjunctive therapy of acromegaly, cabergoline has low efficacy in suppressing growth hormone levels and is highly efficient in suppressing hyperprolactinemia that is present in 20-30% of acromegaly cases; growth hormone and prolactin are similar structurally and have similar effects in many target tissues, therefore targeting prolactin may help symptoms when growth hormone secretion can not be sufficiently controlled by other methods;
Off-label
It has at times been used as an adjunct to SSRI antidepressants as there is some evidence that it counteracts certain side effects of those drugs, such as reduced libido and anorgasmia. It also has been suggested that it has a possible recreational use in reducing or eliminating the male refractory period, thereby allowing men to experience multiple ejaculatory orgasms in rapid succession, and at least two scientific studies support those speculations.
Pregnancy and lactation
Relatively little is known about the effects of this medication during pregnancy and lactation. In some cases the related bromocriptine may be an alternative when pregnancy is expected.
Pregnancy : available preliminary data indicates a somewhat increased rate of congenital abnormalities in patients who became pregnant while treated with cabergoline.
Lactation : In rats cabergoline was found in the maternal milk. Since it is not known if this effect also occurs in humans, breastfeeding is usually not recommended if/when treatment with cabergoline is necessary.
Lactation suppression : In some countries cabergoline (Dostinex) is sometimes used as a lactation suppressant. It is also used in veterinary medicine to treat false pregnancy in dogs.
Contraindications and precautions
Hypersensitivity to ergot derivatives
Pediatric patients (no clinical experience)
Severely impaired liver function or cholestasis
Co-medication with drugs metabolized mainly by CYP P450 such as erythromycin and ketoconazole, because increased plasma levels of cabergoline may result (although cabergoline undergoes minimal CYP450 metabolism).
Cautions: severe cardiovascular disease, Raynaud’s disease, gastroduodenal ulcers, active gastrointestinal bleeding, hypotension.
Side effects
Side effects are mostly dose dependent. Much more severe side effects are reported for treatment of Parkinson’s disease and (off-label treatment) for restless leg syndrome which both typically require very high doses. The side effects are considered mild when used for treatment of hyperprolactinemia and other endocrine disorders or gynecologic indications where the typical dose is one hundredth to one tenth that for Parkinson’s disease.
Cabergoline requires slow dose titration (2–4 weeks for hyperprolactinemia, often much longer for other conditions) to minimise side effects. The extremely long bioavailability of the medication may complicate dosing regimens during titration and require particular precautions.
Cabergoline is considered the best tolerable option for hyperprolactinemia treatment although the newer and less tested quinagolide may offer similarly favourable side effect profile with quicker titration times.
Approximately 200 patients with newly diagnosed Parkinson’s disease participated in a clinical study of cabergoline monotherapy. Seventy-nine (79) percent reported at least one side effect. These side effects were chiefly mild or moderate:
GI tract: Side effects were extremely frequent. Fifty-three percent of patients reported side effects. Very frequent: Nausea (30%), constipation (22%), and dry mouth (10%). Frequent: Gastric irritation (7%), vomiting (5%), and dyspepsia (2%).
Psychiatric disturbances and central nervous system (CNS): Altogether 51 percent of patients were affected. Very frequent: Sleep disturbances ( somnolence 18%, insomnia 11%), vertigo (27%), and depression (13%). Frequent: dyskinesia (4%) and hallucinations (4%).
Cardiovascular: Approximately 30 percent of patients experienced side effects. Most frequent were hypotension (10%), peripheral edema (14%) and non-specific edema (2%). Arrhythmias were encountered in 4.8%, palpitations in 4.3%, and angina pectoris in 1.4%.
In a combination study with 2,000 patients also treated with levodopa, the incidence and severity of side effects was comparable to monotherapy. Encountered side effects required a termination of cabergoline treatment in 15% of patients. Additional side effects were infrequent cases of hematological side effects, and an occasional increase in liver enzymes or serum creatinine without signs or symptoms.
As with other ergot derivatives, pleuritis, exudative pleura disease, pleura fibrosis, lung fibrosis, and pericarditis are seen. These side effects are noted in less than 2% of patients. They require immediate termination of treatment. Clinical improvement and normalization of X-ray findings are normally seen soon after cabergoline withdrawal. It appears that the dose typically used for treatment of hyperprolactinemia is too low to cause this type of side effects.
Valvular heart disease
In two studies published in the New England Journal of Medicine on January 4, 2007, cabergoline was implicated along with pergolide in causing valvular heart disease.
Interactions
No interactions were noted with levodopa or selegiline. The drug should not be combined with other ergot derivatives. Dopamine antagonists such as antipsychotics and metoclopramide counteract some effects of cabergoline. The use of antihypertensive drugs should be intensively monitored because excessive hypotension may result from the combination.
Pharmacology
Although cabergoline is commonly described principally as a dopamine D 2 receptor agonist, it also possesses significant affinity for the D 3, D 4, 5-HT 1A, 5-HT 2A, 5-HT 2B, 5-HT 2C, α 2B – receptors, and moderate/low affinity for the D 1 and 5-HT 7 receptors. Cabergoline functions as an agonist at all of these receptors except for 5-HT 7 and α 2B -, where it acts as an antagonist.
Binding profile
Receptor
Binding Affinity (K i [nM])
Action
5-HT 1A
20.0
Agonist
5-HT 1B
479
Unknown
5-HT 1D
8.71
Unknown
5-HT 2A
6.17
Agonist
5-HT 2B
1.17
Agonist
5-HT 2C
692
Agonist
α 1A adrenergic
288
Unknown
α 1B adrenergic
60.3
Unknown
α 1D adrenergic
166
Unknown
α 2A adrenergic
12
Unknown
α 2B adrenergic
72.4
Antagonist
α 2C adrenergic
22.4
Unknown
β 1 adrenergic
>10,000
Unknown
β 2 adrenergic
>10,000
Unknown
D 1
214
Agonist
D 2S
0.62
Agonist
D 2L
0.95
Agonist
D 3
0.79
Agonist
D 4
56.2
Agonist
D 5
22.4
Unknown
Pharmacokinetics
Following a single oral dose, resorption of cabergoline from the gastrointestinal (GI) tract is highly variable, typically occurring within 0.5 to 4 hours. Ingestion with food does not alter its absorption rate. Human bioavailability has not been determined since the drug is intended for oral use only. In mice and rats the absolute bioavailability has been determined to be 30 and 63 percent, respectively. Cabergoline is rapidly and extensively metabolized in the liver and excreted in bile and to a lesser extent in urine. All metabolites are less active than the parental drug or inactive altogether. The human elimination half-life is estimated to be 63 to 68 hours in patients with Parkinson’s disease and 79 to 115 hours in patients with pituitary tumors. Average elimination half-life is 80 hours.
The therapeutic effect in treatment of hyperprolactinemia will typically persist for at least 4 weeks after cessation of treatment.
Mechanism of action
Cabergoline is a long-acting dopamine D 2 receptor agonist and in vitro rat studies show a direct inhibitory effect on the prolactin secretion in the pituitary’s lactotroph cells. Cabergoline decreased serum prolactin levels in reserpinized rats.
Receptor binding studies indicate a low affinity for dopamine D 1 receptors, α 1 -adrenergic receptors, and α 2 -adrenergic receptors.
Research
Cabergoline was studied in one person with Cushing’s disease, to lower ACTH levels and cause regression of ACTH producing pituitary adenomas.
History
Cabergoline was first synthesized by scientists working for the Italian drug company Farmitalia-Carlo Erba in Milan who were experimenting with semisynthetic derivatives of the ergot alkaloids, and a patent application was filed in 1980.
Farmitalia-Carlo Erba was acquired by Pharmacia in 1993,
Cabergoline was first marketed in The Netherlands as Dostinex in 1992.
See also
Bromocriptine

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