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Amantadine
Amantadine is a prescription medication used to treat Parkinson’s disease, symptoms similar to Parkinson’s disease, as well as used to treat drug-induced extrapyramidal reactions. It also is used to prevent and treat certain viral infections. Amantadine belongs to a class of drugs called antiviral agents, which stop the ability of the virus from spreading. It is not known how it works to treat Parkinson’s disease and similar conditions.
This medication comes in tablet, capsule, extended-release capsule, and syrup forms and is taken once or twice a day, with or without food.
Common side effects of amantadine include nausea, lightheadedness, and insomnia. Amantadine can also cause blurry vision. Do not drive or operate heavy machinery until you know how amantadine affects you.
Amantadine is a prescription medication used to treat patients with Parkinson’s disease and who are being treated with levodopa and is used to treat symptoms similar to Parkinson’s disease. Amantadine is used to treat drug-induced extrapyramidal reactions. It also is used to prevent and treat certain viral infections caused by a type of virus (influenza virus A).
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Amantadine may be found in some form under the following brand names:
Amantadine is part of the drug class:
Serious side effects have been reported with amantadine. See the “Amantadine Precautions” section
Common side effects of amantadine include the following:
This is not a complete list of amantadine side effects. Ask your doctor or pharmacist for more information.
Tell your doctor if you have any side effect that bothers you or that does not go away.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
This is not a complete list of amantadine drug interactions. Ask your doctor or pharmacist for more information.
Serious side effects have been reported with amantadine including the following:
Amantadine can cause drowsiness. Do not drive or operate heavy machinery until you know how amantadine affects you.
Live vaccines are not recommended while taking amantadine. Amantadine may affect how well the live vaccines work.
Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of amantadine, there are no specific foods that you must exclude from your diet when receiving this medication.
Before taking amantadine, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories – A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Amantadine falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.
Tell your doctor if you are breastfeeding or plan to breastfeed.
Amantadine has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants, the use of amantadine is not recommended.Your doctor and you will decide if the benefits outweigh the risk of using amantadine.
Take amantadine exactly as prescribed. 
This medication comes in tablet, capsule, and syrup forms and is taken once or twice a day.  
It also comes in extended-release (long-acting) capsules and tablets that are taken once a day. Do not chew, divide, or break extended-release capsules and tablets. Swallow extended-release capsules and tablets whole. 
Alcohol may intensify some of the side effects (dizziness, light-headedness, confusion) of this medication.
Do not stop this medication abruptly.
If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of amantadine at the same time.
Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
The dose your doctor recommends may be based on the following:
Prevention and treatment of uncomplicated influenza A virus
The recommended adult dose of amantadine for the prevention and treatment of uncomplicated influenza A virus is 200 mg in a single dose and is given within 24-48 hours after onset of symptoms and continued 24-48 hours after symptoms disappear.
In persons 65 years of age or older, the daily dosage of amantadine is 100 mg.
The recommended adult dose of amantadine tablets and liquid for the treatment of Parkinson’s disease or symptoms similar to Parkinson’s disease is 100 mg twice a day when used alone.
The initial dose of amantadine is 100 mg daily for patients with serious associated medical illnesses or who are receiving high doses of other antiparkinson drugs. After one to several weeks, the dose may be increased to 100 mg twice daily, if needed.
The recommended starting dose of Gocovri (amantadine) extended-release capsules is 137 mg by mouth once daily at bedtime. After 1 week, it is recommended that the dose is increased to 274 mg once daily at bedtime. People with lower kidney function may require lower doses.
The recommended starting dose of Osmolex ER  (amantadine) extended-release tablets is 129 mg by mouth once a day in the morning. The maximum dose is 322 mg per day. 
Dosage for Drug-Induced Extrapyramidal Reactions:
The usual recommended dose of amantadine is 100 mg twice a day. For those patients who do not respond to these doses may benefit from an increase up to 300 mg daily in divided doses.
The recommended starting dose of Osmolex ER (amantadine) extended-release tablets is 129 mg by mouth once a day in the morning. The maximum dose is 322 mg per day. 
If you take too much amantadine, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

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