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Alfuzosin is a medication of the α 1 blocker class. It is used to treat benign prostatic hyperplasia (BPH).
As an antagonist of the α 1 adrenergic receptor, it works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.
Alfuzosin was approved by the U.S. FDA for treatment of BPH in June 2003. It is marketed in the United States by Sanofi Aventis under the brand name Uroxatral and elsewhere under the tradenames Xat, Xatral, Prostetrol and Alfural.
1 Side effects
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The most common side effects are dizziness (due to postural hypotension ), upper respiratory tract infection, headache, fatigue, and abdominal disturbances. Side effects include stomach pain, heartburn, and congested nose.
Alfuzosin should be used with caution in patients with severe renal insufficiency, and should not be prescribed to patients with a known history of QT prolongation who are taking medications known to prolong the QT interval.
Alfuzosin contains a stereocenter and is therefore chiral. There are two enantiomeric forms, ( R )-alfuzosin and ( S )-alfuzosin. The drug is used as a racemate, ( RS )-alfuzosin, a 1: 1 mixture of the ( R )- and ( S )-forms.
Enantiomers of alfuzosin
CAS number : 123739-69-5
CAS number.: 123739-70-8
It is provided as the hydrochloride salt.
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